Fig. 1: Flowchart of genetic data processing. | Molecular Psychiatry

Fig. 1: Flowchart of genetic data processing.

From: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Fig. 1

PRS processing was performed in two steps. The first step contained standardised quality check for genetic data and SNP selection. Specific criteria are summarised in the figure and detailed in the Methods. The outputs from the first step were then used for the second step of generating PRS for each individual cohort. All PRS created are summarised in the figure and detailed in the Methods. QC quality check, MAF minor allele frequency, PRS polygenic risk score, PRS-CT PRS created using clumping and thresholding method, PRS-SBayesR PRS created using SBayesR.

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