Fig. 4: Association between PRS-CT at pT=1 and brain regional measures. | Molecular Psychiatry

Fig. 4: Association between PRS-CT at pT=1 and brain regional measures.

From: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Fig. 4

a P-value plot for associations between MD PRS and all regional measures. X-axis represents the three categories of brain regional measures. Y-axis represents -log10-transformed p-values. Each dot represents the result for one brain regional measure. Red and grey dashed lines are the FDR- and Bonferroni-significance threshold, respectively. Associations that are significant after FDR-correction are highlighted as solid dots. Top five FDR-significant associations per category are annotated with labels of regions in the figure. Multiple-comparison correction was applied within each individual category. No associations were found in cortical thickness and therefore only the Bonferroni-significance threshold is shown in the figure. b. Regional results for cortical surface areas. Darker colours represent lower beta-values (standardised regression coefficients). c. Regional results for subcortical volumes in coronal view.

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