Fig. 5: Results of the bi-directional Mendelian randomisation analysis for the causal relationships between MD and neuroimaging traits. | Molecular Psychiatry

Fig. 5: Results of the bi-directional Mendelian randomisation analysis for the causal relationships between MD and neuroimaging traits.

From: Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Fig. 5

The top panel shows the results of causal effects of brain structural measures to MD, and the bottom panel shows the causal effects in the reverse direction. X-axes represent individual brain structural measures, and the measures were separated by their category (global measure/cortical surface area/subcortical volume). Y-axes represent -log10-transformed p-values. Neuroimaging traits were highlighted in the plot if there was any potentially causal effect that reached FDR-significance indicated by the inverse variance weighted method.

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