Table 2 Association of the PGS (as a continuous variable) with baseline and incident depression per different CES-D-10 thresholds.

From: Genomic risk prediction for depression in a large prospective study of older adults of European descent

CES-D-10 threshold

Baseline depression

Incident depression during follow-up

Case No.

Control No.

Model 1.2

Incident case No. during follow-up

Non-depressed No. during follow-up

Model 2.2

OR (95% CI)

P

HR (95% CI)

P

≥8

1096

10,933

1.23 (1.15–1.31)

2.29E-10

3015

7918

1.18 (1.14–1.23)

9.90E-20

≥10

535

11,494

1.28 (1.17–1.40)

3.64E-08

2121

9373

1.23 (1.17–1.28)

4.69E-20

≥12

291

11,738

1.35 (1.20–1.52)

9.75E-07

1412

10,326

1.30 (1.23–1.37)

2.18E-22

  1. Logistic Model 1.2 and Cox Model 2.2 were used to estimate the odds ratio (OR) or hazard ratio (HR) of the polygenic score (PGS) per standard deviation, with 95% confidence intervals (CI). These models were adjusted for age, sex, the first 20 principal components of genetic ancestry, living status, educational attainment, smoking status, alcohol drinking status, and body mass index.
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