Fig. 2: Sustained 80–110 Hz oscillations (HFO) following psilocybin are most pronounced in infralimbic cortex. | Molecular Psychiatry

Fig. 2: Sustained 80–110 Hz oscillations (HFO) following psilocybin are most pronounced in infralimbic cortex.

From: Short- and long-term modulation of rat prefrontal cortical activity following single doses of psilocybin

Fig. 2

A LFP power between 60–120 Hz across all electrode channels spanning the medial prefrontal cortex of one rat, averaged across the 15 min rest period pre- (left) and post- (right) injection of 0.3 mg/kg psilocybin. B Power density from an LFP channel in the cingulate cortex (CG; top), prelimbic cortex (PL, middle) and infralimbic cortex (IL, bottom) during post-injection of 0.3 mg/kg and 1 mg/kg psilocybin. Dotted line denotes interpolated signal. Red line denotes HFO 1/f power difference between raw and interpolated signal. C HFO 1/f power difference across all recorded channels for each rat. Darker hues indicate greater difference in HFO power. Value below denotes anterior-posterior stereotaxic coordinate of the probe placement based on post-mortem reconstruction (N = 6). D HFO 1/f power difference from all LFP electrodes in all rats as a function of their estimated dorsal-ventral location within the prefrontal cortex. Locations were normalised according to the size of each of the three regions assessed. Plot shows data from individual electrodes (dots) and polynomial fits (curves) for each drug condition with shaded areas depicting 95% prediction intervals (N = 6).

Back to article page