Fig. 4: RS-cells and NS-cells of the medial prefrontal cortex respond to systemic psilocybin with heterogeneous changes in firing rate.

A Individual cell firing rate changes during pre- to post-injection rest blocks sorted according to estimated dorsal-ventral location within the prefrontal cortex. Each of the three brain regions (IL, PL, CG) were normalised in size with approximate location of each cell determined by proximity to electrodes along the probe. Cells coloured in white showed either less than a twofold change in firing rates, or the change did not reach significance. Distributions are shown separately for saline (left), 0.3 mg/kg psilocybin (middle) and 1 mg/kg psilocybin (right). Circles denote RS-cells, triangles pointing up denote NS-cells, triangles pointing down denote WS-cells. B Proportion of RS-cells (left) and NS-cells (right) showing a significant decrease (−), increase (+) or no change (0) from baseline to post-injection of psilocybin or saline within each brain region during rest blocks (N = 4). Asterisks denote significant post-hoc chi-squared test differences in the proportion of cells between saline and 0.3 mg/kg or 1 mg/kg psilocybin; ***p < 0.001, **p < 0.01, *p < 0.05, •p < 0.05 but did not survive Bonferroni multiple comparison correction.