Fig. 1: Generation of forebrain-specific EPO KO mice and tissue-specific expression of EPO and EPO receptors. | Molecular Psychiatry

Fig. 1: Generation of forebrain-specific EPO KO mice and tissue-specific expression of EPO and EPO receptors.

From: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors

Fig. 1

A Schematic representation of the generation of the EmxEPO KO mouse line. Forebrain-specific loss of EPO was achieved by crossing the Emx1IREScre driver line with mice carrying a floxed EPO gene. B EPO mRNA expression (normalized to β-actin and Hprt1) in hippocampus, cortex, cerebellum and kidney of EPO KO and WT control mice. C, D EPOR and EphB4 mRNA expression (normalized to β-actin and Hprt1) in hippocampus, cortex, cerebellum and kidney of EPO KO and WT control mice. All data are shown as mean ± SEM with p < 0.05 considered significant. Statistical analyses were conducted via unpaired t-tests with Welch´s correction.

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