Fig. 3: Behavioral phenotyping of mice with forebrain-specific EPO deletion. | Molecular Psychiatry

Fig. 3: Behavioral phenotyping of mice with forebrain-specific EPO deletion.

From: Forebrain-specific loss of erythropoietin provokes compensatory upregulation of different EPO receptors

Fig. 3

A Basic behavioral testing. Schematic displays the outline of behavioral experiments performed on EmxEPO mice, starting at the age of 7 weeks and concluded at the age of 27 weeks. Detailed behavioral results are presented in Table 1. B Higher order cognition was evaluated in our IntelliCage behavioral testing paradigm. Cognition index results for spatial learning and memory, episodic-like memory and working memory are given in scatter bar graphs. A graphical plan of the respective IntelliCage paradigm is presented underneath the bar graphs; HAB habituation, PL place learning, RL reversal learning, MRL multiple reversal learning, ELM episodic-like memory, CW clockwise, CCW counterclockwise, N numbers given in bars; mean ± SEM presented; t-test with Welch’s correction and Mann-Whitney U test were used for statistical analyses. C MRI, matched sample sections demonstrate in an exemplary fashion that there was no difference between WT and EPO KO mutants.

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