Fig. 2: Results of analyzing differences in endophenotypes across each cohort, together with the significant associations between the top 20 DMPs identified in each EWAS and each endophenotype. | Molecular Psychiatry

Fig. 2: Results of analyzing differences in endophenotypes across each cohort, together with the significant associations between the top 20 DMPs identified in each EWAS and each endophenotype.

From: Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents

Fig. 2

Judicial Autopsy Cases: (A) Group comparison of thymus weight ratio (t = −2.9, P = 0.008). Error bars represent SEM. B Correlation plots for the seven DMPs that showed significant associations with thymus weight ratio. See Supplementary Table S3 for detailed statistical analyses. Toddler Social Cognition: (C) Correlation plots for the two DMPs significantly associated with visual attention to the eyes. See Supplementary Table S5 for full statistical details. Adolescent Brain Imaging: (D) Whole-brain GMV comparison using Voxel-Based Morphometry (VBM). The three identified brain regions are R.OFrC (Right Orbitofrontal Cortex), L.MPCG (Left Medial/Posterior Cingulate Gyrus), and L.OFuG (Left Occipital Fusiform Gyrus). Color bars indicate t-statistics. E Heatmap showing correlations between the top 20 DMPs and the GMVs of these three regions. Asterisks denote significance levels (*P < 0.05, **P < 0.01, ***P < 0.005). F Correlation plots for the DMPs significantly associated with each regional GMV: 13 (R.OFrC), 3 (L.MPCG), and 12 (L.OFuG). See Supplementary Table S8 for detailed statistical analyses.

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