Fig. 5: Receiver Operating Characteristic (ROC) curves for logistic regression models incorporating the Methylation Risk Scores (MRS) in an independent public dataset (GSE118940).

A The coefficient estimates obtained from logistic regression models (with and without adjustment for age, sex, and blood cell proportions) for the four probes that constituting the MRS. B ROC curves illustrating the classification performance of these logistic regression models. AUC: area under the curve; Sens: sensitivity; Spec: specificity. C Box plot presenting the adjusted-model MRS values in the institutional care (IC) and the biological family care (BFC) group. Error bars indicate the standard error of the mean (SEM).