Table 2 Plasma concentrations of sex hormones and history of menstruations.

From: Impact of acute anorexia nervosa and of short-/long-term recovery after refeeding on the hormonal profiles of activin A, GDF-15 and follistatins

  

acAN_T1

acAN_T2

recAN_OCP−

HC_OCP−

recAN_OCP+

HC_OCP+

Group

 

1

2

3

4

5

6

N

 

79

79

35

79

45

41

LH (U/L)

 

2.51 ± 0.47

9.28 ± 1.12

11.40 ± 2.57

9.31 ± 1.04

3.21 ± 0.52

4.07 ± 0.66

P

2, 3, 4, 6

1

1, 5

1, 6

3

1, 4

PA

2, 3, 4

1

1, 5

1, 6

3

4

PAB

2, 3, 4

1

1, 5

1, 6

3

4

PAC

2, 3, 4

1

1, 5

1, 6

3

4

FSH (U/L)

 

4.578 ± 0.43

5.89 ± 0.31

6.14 ± 0.48

5.62 ± 0.28

3.19 ± 0.38

3.55 ± 0.40

P

ns

ns

5

6

3

4

PA

2, 4

1

5

1,6

3

4

PAB

2, 4

1

5

1

3

ns

PAC

2, 4

1

5

1, 6

3

4

Estradiol (pmol/L)

 

105.7 ± 25.13

250.1 ± 35.57

424.5 ± 76.52

360.5 ± 37.63

93.33 ± 16.32

98.62 ± 15.43

P

2, 3, 4

1, 4

1, 5

1, 2, 6

3

4

PA

2, 4

1, 4

5

1, 2, 6

3

4

PAB

2, 4

1, 4

5

1, 2, 6

3

4

PAC

2, 4

1, 4

5

1, 2, 6

3

4

Leptin (ng/ml)

 

1.72 ± 0.30

N = 76

12.60 ± 0.77

N = 78

7.76 ± 0.61

N = 32

11.02 ± 1.05

N = 75

9.92 ± 0.96

N = 42

14.22 ± 1.55

N = 35

P

2, 3, 4, 5, 6

1

1

1

1

1

PA

2, 3, 4, 5, 6

1, 4

1

1,2

1

1

PAB

2, 3, 4, 5, 6

1

1

1

1

1

PAC

2, 3, 4, 5, 6

1

1

1

1

1

Menorrhea + 

(y/n/u)

(10/56/13)

(19/48/12)

(34/0/1)

(76/0/3)

(43/0/2)

(39/0/2)

Days since last menstruation

 

24.63 ± 9.30

N = 8

12.63 ± 1.73

N = 16

16.29 ± 1.63

N = 34

16.59 ± 1.58

N = 74

17.52 ± 1.95

N = 42

12.39 ± 1.14

N = 38

P

ns

ns

ns

ns

ns

ns

McNemar’s Test

 

p-value(2tail) 0.0133

    
  1. acAN_T1, acute anorexia nervosa at timepoint 1; acAN_T2, acute anorexia nervosa at timepoint 2 (after short-term refeeding); recAN, long-term recovered anorexia nervosa; HC, healthy control group; OCP−, no oral contraception; OCP+, with oral contraception. The groups are coded from 1 to 6 and P indicates only the groups with which each respective group differs significantly at a p-value adjusted for multiple comparisons, i.e. p < 0.006. The comparisons were 9 in total: acAN_T1 [1] vs each other group [2,3,4,5,6], acAN_T2 [2] vs HC_OCP− [4], recAN_OCP− [3] vs HC_OCP− [4], recAN_OCP− [3] vs recAN_OCP+ [5], HC_OCP− [4] vs HC_OCP+ [6]. PA indicates additional adjustment for age; PAB indicates additional adjustments for age and current smoking, PAC indicates additional adjustment for age and antidepressant use; no participants were taking antidepressants in comparisons of groups 1 vs 4, 1 vs 6 and 4 vs 6, thus PAC is the same as PA in these comparisons. LH, FSH, estradiol different N (T1 = 60, T2 = 60, recAN_OCP− = 33, HC_OCP− = 72, recAN_OCP+ = 44, HC_OCP+ = 39); OCP either progesterone, estrogen, or both. Menorrhea+: Self-reported menstrual cycle in the last 3 months, y = yes, n = no, u = unknown, not reported. For participants under OCP (OCP+), menstruation refers to withdrawal bleeding. Mean ± Std. Error of Mean are presented. Different n for Menorrhea+ vs Days since last menstruation is due to inability of few study participants to remember the exact date of last Menstruation. For the exact p-values for each comparison refer to supplemental Table 2.
Back to article page