Fig. 1: Associations between caffeine metabolic ratios, clinical covariates in SKIPOGH and CoLaus|PsyCoLaus. | Molecular Psychiatry

Fig. 1: Associations between caffeine metabolic ratios, clinical covariates in SKIPOGH and CoLaus|PsyCoLaus.

From: Dietary caffeine to assess CYP1A2 activity, tailor clozapine doses, and predict treatment response: genetic, epigenetic and clinical analyses

Fig. 1

Number of observations varies due to missing values. Covariates selected using backward procedure. Of note, due to the design of the SKIPOGH study (i.e., a multicenter study), the center effect was included in the analyses; however, as it failed to show statistically significant effect, it was excluded from the model. *p < 0.05, ** p < 0.01, *** p < 0.001. 1 Box-cox transformed to insure normal distribution. 2 Including smoking. 3 log transformed to better approximate a normal distribution. 4 The kidney function was estimated by the glomerular filtration rate (eGFR) calculated using Chronic Kidney Disease - Epidemiology Collaboration formula (by 10 ml/min/1.73 m2). hs high sensitivity. Example of interpretations: In SKIPOGH, CYP1A2 inducer users and alcohol consumers, had a 36 and 9% increased CMR as compared to non-CYP1A2 activity inducer users and non-alcohol consumers, respectively. For each one unit increase in log hs C-reactive protein levels, CMR decreased by 6%, while for each 10-year increase in age and 10 ml/min/1.73 m2 increase in eGFR, CMR increased by 7 and 4%, respectively.

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