Fig. 2: Hippocampal ePRS for SGK1 predicts depression and moderates an association between ELA and depression. | Molecular Psychiatry

Fig. 2: Hippocampal ePRS for SGK1 predicts depression and moderates an association between ELA and depression.

From: Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk

Fig. 2

A Diagram of SGK1 ePRS calculation. B Hippocampal SGK1 ePRS is higher in depressed children compared to non-depressed children. C Higher hippocampal SGK1 ePRS is associated with more depressive symptoms. D SGK1 ePRS moderates an association between ELA and depressive symptoms, and E between ELA and suicide attempts. Number of adversities: 0, 1, 2, 3, or ≥4. ELA – Early Life Adversity. ePRS – expression-based polygenic risk score. *p < 0.05; **p < 0.01.

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