Fig. 4: SGK1 inhibition promotes stress resilience in mice. | Molecular Psychiatry

Fig. 4: SGK1 inhibition promotes stress resilience in mice.

From: Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk

Fig. 4

A Timeline and workflow for detecting GSK650394 in hippocampus tissue. B Systemic injections of GSK650394 result in detectable drug concentrations in the hippocampus. C Timeline of CSDS experiment with SGK1 inhibition using systemic GSK650394 injections. D GSK650394 does not affect interaction with a novel enclosure. E GSK650394 prevents a CSDS-induced reduction in social avoidance. F GSK650394 prevents a CSDS-induced increase in the fraction of susceptible mice based on their SI ratio. G GSK650394 increases the time mice spend in the center of the OF arena, and H rearing bouts in the OF. I GSK650394 prevents a CSDS-induced reduction in mobility during the last 4 min of the FST. CSDS – Chronic Social Defeat Stress; SI – Social Interaction; OF – Open Field; FST – Forced Swim Test. *p < 0.05; **p < 0.01.

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