Fig. 3: NMDA channel blockade is affected by Alzheimer’s disease in right parietal cortex. | Molecular Psychiatry

Fig. 3: NMDA channel blockade is affected by Alzheimer’s disease in right parietal cortex.

From: Alzheimer’s disease and memantine effects on NMDA-receptor blockade: non-invasive in vivo insights from magnetoencephalography

Fig. 3

The PEB posterior estimate of the expected value of the NMDA channel blockade parameter for each person with Alzheimer’s disease are shown. This NMDA-blockade parameter is re-estimated during the second-level PEB analysis. NMDA channel blockade (a) correlates with MMSE (posterior estimate of the second-level NMDA channel blockade parameter=0.06, posterior probability = 0.99) and (b) reduces further at follow-up compared to baseline (posterior estimate of the second-level NMDA blockade parameter = −0.125, posterior probability = 0.97). Lines are weighted by each subject’s average precision of NMDA blockade over sessions. MMSE mini-mental state examination, PEB parametric empirical Bayes.

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