Fig. 1: Amanida-based meta-analysis.
From: Rethinking Alzheimer’s: novel miRNAs illuminate a disease beyond the brain
A Volcano plot showing Amanida-derived meta-analysis results. Red circles correspond to miRNAs with compound P-values -log10 > 1.301 and pseudo-T-scores >1.96, yellow and grey circles correspond to miRNAs with compound P-values -log10 > or < 1.301, respectively. B Venn networks showing the prevalence of significantly up- (pink) and down- (green) regulated miRNAs described (yellow) or not (grey) in the brain in AD patients compared with healthy subjects (average expression level ≥ 10 rpmm). C Presence of “AD miRNAs” in individual tissues based on the miRNATissueAtlas version 2025 (one miRNA was not present in the TissueAtlas database). Only 10 tissues with the highest average miRNA expressions (rpmm normalized counts) are displayed for each miRNA changed in AD. D The top 10 most significantly enriched and top neurodegeneration-related PANTHER knowledgebase forecast biological pathways based on the strong targets of significantly up- and down-regulated miRNAs found in brain or other tissues in AD patients compared with healthy subjects. E Sankey plot showing targets known to be involved in the pathogenesis of AD including targets involved in impaired axonal transport for up- (pink) and down- (green) regulated miRNAs in AD patients compared with healthy subjects. MiRNAs with more than 3 related AD targets are displayed in the left panel. F Combined barplot of Vesiclepedia-predicted proportions of miRNAs found in extracellular vesicles (EVs) (P = 0.708) and percentage of secretion-promoting EXO motifs (P = 0.00002) in AD patients compared with healthy subjects.
