Fig. 3: Key AD-related miRNAs.
From: Rethinking Alzheimer’s: novel miRNAs illuminate a disease beyond the brain
A Number of miRNAs identified as known or unknown to play roles in AD pathogenesis based on their targets. Circular dendrograms show proportion of targets involved in biological processes of miRNAs known or unknown to play roles in AD pathogenesis. Minimum shared target was set to 3. B Most significant PANTHER knowledgebase forecast biological pathways identified for the minimum of 3 shared targets of AD known and unknown miRNAs. C Sankey plot showing tissue specificity for AD known and unknown miRNAs. The top 3 individual tissues per miRNA based on miRNATissueAtlas version 2025 database are shown (average expression level ≥10 rpmm). Line thickness represents the miRNA expression level in individual tissue (log10(rpmm)=1to6). D Top 10 complex interactions and disease related pathways (KEGG) for AD known and AD unknown miRNAs.
