Table 1 Hierarchy of MAIT cell antigen potencies

From: Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

EC50 values (M)

MAIT cells

TRBV

5-OP-RU

5-OE-RU

RL-6,7-diMe

SMC3a

20-1

5.329e−14

1.45e−10

4.603e−08

MRC25a

6-1

8.757e−13

2.731e−09

2.332e−06

Donor 7b

Polyclonal

3.083e−10

1.030e−08

2.618e−05

Donor 8b

Polyclonal

3.027e−10

8.920e−09

3.267e−05

Donor 9b

Polyclonal

1.888e−11

7.558e−10

1.970e−05

Donor 10b

Polyclonal

2.949e−10

2.501e−09

1.887e−05

Donor 11b

Polyclonal

1.864e−10

nd

8.189e−06

  1. nd not done
  2. a EC50 calculated by IFNγ response
  3. b EC50 calculated by TCR Vα7.2 downmodulation at 24 h