Fig. 7
Tc2 cell activation in response to mast cell supernatant containing endogenous PGD2 and LTE4 is mediated by receptors sensitive to TM30089 and montelukast, respectively. a Levels of PGD2 (black bars) and LTE4 (white bars) were increased in supernatants from mast cells stimulated with IgE and anti-IgE antibodies (supernatant SM) compared with supernatants from cells without stimulation (supernatant UM). b More Tc2 cell migration to supernatant SM (white bars) than to supernatant UM (grey bar) in a chemotaxis assay was reduced by TM30089 and montelukast. c IL-5 and IL-13 productions in Tc2 cells were significantly increased in response to supernatant SM (white bars) compared with that to the supernatant UM (grey bars), and were inhibited by TM30089 and montelukast. *p < 0.05, **p < 0.005 (n = 3 for a and b; n = 4 for c)
