Fig. 6

TRAG colitis is microbially driven, restricted to the colon, and independent of group 3 ILCs. (a) Histology and histological cores showing suppression of colitis in antibiotic treated TRAG mice (ABX TRAG). Lack of small bowel and systemic inflammation in TRAG mice. (b) Histology showing absence of ileitis (upper panel H&E) and preservation of Paneth cells (lower panel red = lysozyme) in the terminal ileum and (c) lack of hepatitis in liver of RAG1^−/− or TRAG mice. (d) Flow cytometry and total cell counts of spleen showing lack of expansion of CD45⁺ leukocytes in the primary immune tissue of TRAG mice (inset: picture of spleens). (e) Histology showing that colitis is not prevented in TRAG x Rorc^−/− mice and (f) in TRAG mice treated with anti-TNF antibody