Fig. 5
From: Osteopontin protects against lung injury caused by extracellular histones
OPN binds to citrullinated histone tails. SPR sensorgrams illustrating interactions between OPN and citrullinated histone tails. OPN was covalently bound to a CM5 sensor chip using a standard amine-coupling kit. Native and citrullinated peptides derived from H2A, H3, and H4 subunits were injected over the sensor chip to determine binding. Both native and citrullinated fragments bound OPN, but the latter to a lower degree
