Fig. 5 | Mucosal Immunology

Fig. 5

From: Novel role of gastrin releasing peptide-mediated signaling in the host response to influenza infection

Fig. 5

Blocking GRP blunts influenza-induced cytokine induction in vivo. WT C57BL/6J mice (5 mice/treatment group) were infected i.n. with mouse-adapted influenza strain PR8 (LD90; ~7500 TCID50). Mice received vehicle (saline + 0.0096% DMSO) or GRP inhibitor (NSC77427; 20 μM/mouse; i.v.) daily from day 2 to day 6 post infection. On day 7 post-infection, lungs were harvested and total RNA was extracted to measure gene expression by qRT-PCR. **p < 0.01; *p < 0.05

Back to article page