Fig. 3
From: Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection
Functional unbalance and microbial adaptation to oxidative stress. a Microbial functions significantly correlated with gene richness (Benjamini–Hochberg-corrected Spearman Rank correlation p value < 0.05) in both MSM and non-MSM subjects. b Differential enrichment in microbial enzymes involved in metabolism of reactive oxygen species (ROS) in LGCs (upper horizontal bars) vs. HGCs (lower horizontal bars), and contribution of microbial species to such enrichment. The plot shows significant differences in ROS gene enrichment between LGC and HGC (diamond, Wilcoxon test statistic) using a false discovery rate p value threshold of 0.05. Microbes are colored by phyla, i.e., Bacteroidetes in purple; Firmicutes in blue; Proteobacteria in red, Others in gray. c Abundance of microbial enzymes involved in ROS metabolism by nadir CD4+ T-cell count categories. G6PHD, glucose-6-phosphate dehydrogenase; 6pgd, 6-phosphogluconate dehydrogenase; gr, glutatione reductase; gpx, glutathione peroxidase; ahpc, peroxiredoxin AhpC; bcp, peroxiredoxin BCP; tpx, atypical 2-Cys peroxiredoxin; cat, catalase; sod2, superoxide dismutase Fe–Mn; msra, methionine sulfoxide reductase A
