Fig. 8 | Mucosal Immunology

Fig. 8

From: CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17

Fig. 8

Proposed model for how CCR2 deficiency mediates increased neutrophil accumulation and bacterial killing. In the absence of CCR2+ monocytes, CD103+ dendritic cells respond to influenza by producing high levels of IL-6, IL-23, and IL-1β. These pro IL-17 cytokines in conjunction with decreased production of IL-27 result in robust skewing of Th17 cells as well as IL-17 secreting γδ T-cells and iNKT cells. IL-17 can activate type II alveolar epithelial cells to produce the neutrophil recruiting chemokines CXCL1/2 which promote the infiltration of bactericidal neutrophils into the lung in response to a subsequent MRSA infection

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