Fig. 4 | Mucosal Immunology

Fig. 4

From: Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Fig. 4

Age-associated shifts in the ileal microbial community composition detected in non-IBD controls are not present within CD. a PCoA with Bray−Curtis distance comparing microbial community diversity in samples from CD patients (n = 272) and Ctl (n = 178). Left panel, samples are colored by the Chao1 diversity index. Right panel, samples are colored by <10 and ≥10 years. Triangular shape indicates Ctl, filled circles indicate CD samples. b Mean and standard deviation of Chao1 α-diversity is shown for Ctl and CD divided in younger <10 and older ≥10 years. *P < 0.01, a two-sided t-test was used. c The bar graph shows fold change (mean older A1b Ctl/mean younger Ctl) for significant associations between the indicated taxa as determined by MaAsLin while taking Paris age, gender, and body mass index (BMI) into account

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