Fig. 5 | Mucosal Immunology

Fig. 5

From: Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Fig. 5

Co-variation of the ileal microbial community structure with host gene expression. a The bar graph shows fold change (mean CD/mean Ctl) for significant associations between the indicated taxa and clinical phenotype (Ctl, CD) as determined by MaAsLin while taking Paris age, gender, body mass index (BMI, as a measure of nutritional status), endoscopic severity (deep ulcers in ileum), clinical severity (Pediatric Crohn’s Disease Activity Index, PCDAI), antibiotics, ileal gene expression of CSF2, CXCR1, IFNG, MMP3, DEFA5, GSTA1, and LCT, and NOD2, and ATG16L1 IBD risk allele carriage into account. b Scatter plots are shown for significant associations between the indicated taxa (y-axis) and host gene expression (x-axis) based on the multivariate statistical analysis described in a

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