Fig. 7
SCF receptor mutant W/Wv mice demonstrated the important role of the SCF-c-Kit activation during chronic allergic diseases. The lack of c-Kit signaling reduces the allergen-induced (a) airway inflammation and mucus deposition in airway by histopathology, PAS staining (b) qPCR of mucus-related genes Muc5 and Gob5, c qPCR of lung cytokines IL-4 and IL-13 expression, d decreased numbers of Mast cells, Eosinophils and ILC2 in the lung. Data represent mean ± SE from each group with 4 to 5 mice/group. All data are representative of two independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001
