Fig. 6
From: A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies
IL-9 is required for in vivo mucosal inflammation driven by TH9-TL1A cells. TH9 or TH9-TL1A cells were injected into Rag1−/− mice and mice were treated three times per week with anti-IL-9 antibody or isotype control. a Representative H&E stainings of the duodenum. Scale bar: 200 μm. b Histology scores for the intestine. c Total MLN cell counts (left), frequency of CD45.1+ cells (middle), and total cell counts of CD45.1+ cells (right). d ELISA analysis of IL-9, IL-17, and IL-13 production from MLN after ex vivo restimulation with anti-CD3 and anti-CD28. Data represent means ± SD of one independent experiment out of two independent experiments. n = 4–5/group. *p < 0.05, **p < 0.01, as determined by Student’s t test (b) or Mann–Whitney U test (c, d)
