Fig. 3

Antibiotic-altered composition differs between Nod2^−/− and WT littermates in neonatal period. Taxonomic differences were identified by linear discriminant analysis (LDA) coupled with effect size (LEfSe). a Taxonomic differences between water vs. antibiotic-treated Nod2^−/− mice at day 21. Taxa enriched in water-treated are shown in black; taxa enriched in antibiotic-treated are red. Taxa that differed between WT and Nod2^−/− mice are indicated (asterisk). b Taxonomic differences between water vs. antibiotic-treated Nod2^−/− mice at day 35. Taxa enriched in water-treated are shown in black; taxa enriched in antibiotic-treated are red. Taxa that differed between WT and Nod2^−/− mice are indicated (asterisk). c Heat map of significant bacterial taxa using Euclidean distance and centroid linkage clustering module (blue: low abundance; yellow: high abundance). Values were generated using the median of each group at each time point