Fig. 7 | Mucosal Immunology

Fig. 7

From: Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism

Fig. 7

Schematic showing putative initiating (CysLT2R-dependent) and downstream (CysLT1R and CysLT3R) dependent effects of cysLTs in driving the mechanism responsible for reactions to aspirin. Platelet CysLT2R is essential to initiate HMGB1/RAGE signaling that permits platelet activation and conjugation to granulocytes. Platelets adherent to granulocytes and activated via CysLT2R/HMGB1/RAGE provide a pool of IL-33 that drives MC activation and a secondary surge of cysLTs to act at cognate receptors, and also activates ILC2s to promote additional type 2 immunopathology

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