Fig. 4
From: The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis
EBI2 promotes inflammation in the IL-10 colitis model. EBI2−/−IL10−/− and IL10−/− male mice were sacrificed after onset of rectal prolapse or at the age of 120 or 200 days. Histological scoring (a) and representative images (b) from HE-stained colon sections from 200 days old mice. Scale bars: 200 µm. (c) Spleen weight of animals from (a). (d) Onset of prolapse in EBI2−/−IL10−/− and IL10−/− mice depicted in a survival curve. Each animal represents an independent observation from continuous breeding > 12 months. Data shown as mean ± SEM. Statistical analysis: Mann–Whitney U test; *p < 0.05, **p < 0.01
