Fig. 7 | Mucosal Immunology

Fig. 7

From: Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis

Fig. 7

a Schematic working model. Intestinal injury induces the expression of IL-23 in Cx3cr1+ mononuclear phagocytes in an mTOR/autophagy-dependent manner. IL-23 stimulates the expression of IL-22. This induction is not necessarily dependent on T and B cells. IL-22 possesses a pro-fibrotic effect by promoting the proliferation and transformation of fibroblasts into myofibroblasts. IL-22 and TGFβ exert a pro-fibrotic effect synergistically. Mechanistically, IL-22 up-regulates the expression of TGFβ RII, thus priming fibroblasts to become fibrotic

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