Fig. 2

Mice pre-treated with INH/PYZ show higher susceptibility to Mycobacterium tuberculosis infection. a Schematic representation for ATT and Mtb infection. Mice were treated with RIF or INH/PYZ for 8 wks. Treatment was stopped 2 days prior to Mtb infection. One group of treated mice received faeces collected from naive mice at −1d, + 1d, + 3d, + 5d of Mtb infection (n = 5/group). Bacterial burden in lungs and spleen of b, c INH/PYZ and INH + PYZ + FT; d, e RIF and RIF + FT-treated mice. f, g Bacterial burden in lungs and spleen of mice treated with RIF/INH/PYZ (RHZ) as described in a. Data shown are pooled from two b–e and one f and g independent experiments. h Relative abundance of Clostridia cluster XIV bacteria (n = 4–5/group). Data shown are representative of two independent experiments. Error bars represent mean ± SEM; *p < 0.05