Fig. 3
From: Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis
Mycobacterium tuberculosis-infected mice pre-treated with INH/PYZ show no differences in antigen-specific T-cell responses. a–g Mice were treated with RIF or INH/PYZ for 8 wks. Treatment was stopped 2 days prior to Mtb infection. One group of treated mice received faeces collected from naive mice at −1d, + 1d, + 3d, + 5d of Mtb infection (n = 5/group). a, b, and e Frequency of TB10.4(4–11) specific CD8 + T cells and c, d ESAT-6(4–17)-specific CD4 T + cells. f T-bet + or g FoxP3 + CD4 T cells in the lungs (n = 5/group) at 4 weeks post infection with Mtb. Data shown are representative of two independent experiments. Error bars represent mean ± SEM
