Fig. 9 | Mucosal Immunology

Fig. 9

From: Alcohol-induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis, and inflammasome-IL-18 activation in the proximal small intestine in mice

Fig. 9

Alcohol-induced CHOP induction, IL-18 activation and PC increases are mediated by the gut microbiota load. a Gut decontamination using broad-spectrum antibiotics administration (Abx; ampicillin, neomycin, vancomycin and metronidazole) significantly reduced the gut microbiota load. CHOP and IL-18 activation were measured from PSI of PF and 10 day EtOH 9 h binge mice by Western blot and quantified (b). c Representative images and (d) quantification of lysozyme immunohistochemistry (IHC) from PF and 10 day EtOH 9 h binge alcohol-fed mice. n = 6–10 mice/group; p < 0.05 * vs. pair-fed, ° vs. 10 day EtOH 9 h binge

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