Fig. 2 | Mucosal Immunology

Fig. 2

From: T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming

Fig. 2

Reduced lung accumulation and differential expression of homing markers by Tbx21−/− effector cells. 1 × 106 naïve WT or Tbx21−/− OT-II cells were adoptively transferred to congenic (CD45.1+) WT hosts and challenged with a sublethal dose of PR8-OVAII. At 7 dpi, a the frequency and (b) total number of donor cells was determined in stated organs from 4 mice/group, with (c) representative staining for the nuclear proliferation marker Ki67 shown in stated organs for host CD4 T cells (solid), WT OT-II cells (black) and Tbx21−/− OT-II cells (grey). d Representative staining (left) and accompanying MFI analysis (right) from donor cells in the lungs from 3 mice/group for (d) CD11a, (e) CXCR3, and (f) CCR4. Results presented from 1 of 3 similar experiments

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