Fig. 3
From: A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract
DN cells in the tissue differ from those in the blood and show a characteristic migration and inflammatory pattern. a Heat map showing the RNA expression pattern of CD8+T-cells for a set of genes differentially expressed in blood DN versus tissue DP cells. b Volcano plot of genes differentially expressed in CVT tissue DN versus blood DN CD8+T-cells (red = upregulated, blue = downregulated genes). c Pathways enriched in the gene set upregulated in tissue DN versus blood DN. (Red = cell migration pathway, purple = inflammatory pathway, green = localization pathway). d The mean frequencies (±SD) of migrated cells as percentages of non-migrated cell in response to S1P, CCL19, and CCL21. Statistical significance was determined by unpaired t-test. n = 3 donors, *p < 0.05, **p < 0.01. e Pearson correlations between the frequencies of DN cells in the vagina and the concentrations of MIP-1a (top panel) and IP10 (bottom panel) in the paired cervicovaginal secretions. Pearson correlation (R2) and p value are indicated in the graph
