Fig. 5
From: A pro-inflammatory CD8+ T-cell subset patrols the cervicovaginal tract
Cervicovaginal tissue CD8+ T-cells exhibit distinctive features as compared to CD8+ T-cells from other tissues. a Gene set enrichment analyses showing overlap between upregulated (red) and downregulated (blue) genes in the CD69+CD8+ T-cell population as compared to DN CD8+ T-cells in the CVT and in previously published gene sets for lung and spleen. b Venn diagram showing the numbers of overlapping and non-overlapping genes in the two gene sets analyzed. c Mean frequencies (±SD) (top) and representative plots (bottom) of CD8+ T-cells producing IL-17A and IL-2 upon a 5 h-PMI/ionomycin stimulation as determined by flow cytometry. To test for statistical significance, a Kruskal–Wallis test was performed with Dunn’s multiple comparisons test. **p < 0.01
