Fig. 6

Neutrophils and T cells can express a similar range of cytokines in lung granulomas. Lung granulomas (n = 16) were disaggregated into single-cell suspensions for analysis by flow cytometry. a Proportion of cytokine-expressing T cells and neutrophils (PMNs) in lung granulomas. b Comparison of relative cytokine expression (relative MFI) for cytokine-positive T cells and neutrophils in lung granulomas. To be included, a granuloma must have cytokine-positive neutrophils and T cells. c Polyfunctionality in lung granuloma T cells (left) and neutrophils (right). d Mean frequencies of different polyfunctional phenotypes in granuloma T cells and neutrophils. e Grouped polyfunctional phenotypes in granuloma T cells and neutrophils. Each marker indicates one granuloma, and each color represents a different monkey. Statistical comparisons of paired data determined by Wilcoxon Matched-Pairs Signed Rank test