Table 1 Distribution of TOLLIP rs5743854 G allele in Netherlands cohort
From: TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia
Control | Cases | P value | Odds ratio (95% CI) | |
|---|---|---|---|---|
N | 309 | 88 | ||
Male, f* (n) | 0.51 (159) | 0.52 (44) | 0.128 | |
Age (median, IQR) | 49.6 (35.2–56.1) | 64.7 (54.2–71.5) | <0.001 | |
Smoker, f*(n) | 0.31 | 0.49 | 0.022 | |
COPD, f (n) | 0.10 (24) | 0.07 (6) | ||
Diabetes mellitus, f (n) | 0.04 (3) | 0.09 (8) | ||
Cancer, f(n) | 0.02 (2) | 0.04 (4) | ||
Hx. transplant, f(n) | 0.02 (2) | 0 (0) | ||
Autoimmune Dz, f(n) | 0 (0) | 0.02 (2) | ||
Alcohol use, f(n) | 0.73 (61) | 0.35 (32) | ||
Rs5743854 genotype | 0.008 | 0.35 (0.16–0.76)† | ||
C/C f (n) | 0.32 (99) | 0.33 (29) | ||
G/C | 0.41 (127) | 0.52 (46) | ||
G/G | 0.27 (83) | 0.14 (12) |
