Fig. 2 | Mucosal Immunology

Fig. 2

From: Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction

Fig. 2

Outline of the effects of DSS treatment on the colon tissue proteome of rhesus macaques. List of significantly regulated proteins (adjusted p value <0.05, BH correction) between DSS chronic and DSS-untreated RMs. Multiple components belonging to each of the five complexes important in oxidative phosphorylation were downregulated. Enzymes involved in short- and long-chain fatty acid metabolism inside the mitochondria were also downregulated. Upregulated components include proteins involved in the actin cytoskeleton and focal adhesion. There was also significant upregulation of complement components related to innate immune activation and coagulation. All pathways were determined to be significantly upregulated in DSS chronic RMs as per DAVID analysis (adjusted p value <0.05, BH correction)

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