Fig. 1
Increased colitis susceptibility in Cybanmf333 mice. DSS colitis in male WT and Cybanmf333 mice. Body weight change (a), disease scores (b), colon length (c), histology scores (d), representative images of H&E stained colon sections (e), and survival curve (f) of DSS-treated WT and Cybanmf333 mice. Rectal temperature measured at days 0 and 6–8 (g), relative expression of colonic Reg3g mRNA at day 7 of DSS colitis (h), and bacterial translocation to the liver expressed as colony forming units (CFUs) at days 7 and 8 of DSS colitis (i). TNBS colitis in male WT and Cybanmf333 mice. Scheme of TNBS model (j), body weight change (k), survival curve (l), colon weight/length ratio (m), and histology scores (n). Data are presented as mean ± SEM of one (h, k–n) or two (a–f, g, i) independent experiments. Each symbol represents an individual mouse; n = 5–6 for control and n = 11–13 for DSS groups (a–f); n = 16 (g, i); n = 6–7 (h); n = 3 for control and n = 6 for TNBS groups (k–n). Data were analyzed using two-way ANOVA followed by Bonferroni post hoc test (a, b, g, k), Mantel–Cox test (f, l), or unpaired t-test (c, d, h, i, m, n). *P < 0.05, **P < 0.01, and ***P < 0.001 vs WT + DSS or TNBS. Scale bar 100 μm
