Fig. 2: IL-22-deficiency prevents the development of spontaneous colitis in Il10−/− mice.
From: The development of colitis in Il10−/− mice is dependent on IL-22
a Prevalence of rectal prolapse (n = >60 per group) in WT, Il10−/−, Il22−/−, and Il10−/−Il22−/− mice. b Representative gross images of organs of the gastrointestinal tracts from each strain. c Colon length for each strain (n = 11 per group). d Representative photomicrographs of haemotoxylin and eosin stained colons (×20). e Histological disease scores (n = 8/group). f Fecal Lcn-2 levels (n = 8/group). Statistical analyses (***p < 0.0001) using the Mann–Whitney U test (error bars represent SEM).
