Fig. 5: Siglec-8 mAb treatment decreases local and systemic cytokines and chemokines induced by IL-33. | Mucosal Immunology

Fig. 5: Siglec-8 mAb treatment decreases local and systemic cytokines and chemokines induced by IL-33.

From: A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

Fig. 5

a–f Levels of IL-6, CCL2, CXCL2, CXCL1, TNF, and IL-13 in the peritoneal cavity and (G-H) CCL2 and CXCL1 in the serum of mice treated with PBS (black), ISO + IL-33 (gray) or anti-S8 + IL-33 (blue). Data are plotted as mean ± SEM (9–10 mice/group) and are representative of at least four experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 by one-way ANOVA with Tukey’s multiple-comparisons test. ISO isotype control, PBS phosphate-buffered saline.

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