Fig. 1: Activation of the NLRP6 inflammasome after Listeria and S. aureus infections. | Mucosal Immunology

Fig. 1: Activation of the NLRP6 inflammasome after Listeria and S. aureus infections.

From: The NLRP6 inflammasome in health and disease

Fig. 1

Cytosolic delivery of Listeria or its toxin (LTA) upregulates the expression of caspase-11 and NLRP6 via triggering of Type 1 IFN signaling in macrophages. NLRP6 then recruits ASC (via PYD–PYD interaction) and caspase-1 and caspase-11 (via CARD–CARD interaction) to form the NLRP6 inflammasome complex. The activated inflammasome cleaves pro-IL-1β and pro-IL-18 into their active forms, which are then secreted from the cell. During S. aureus inflection, NLRP6 is upregulated and recruits ASC and caspase-1, as mentioned above, to form the NRLP6 inflammasome complex. Inactive forms of IL-1β and IL-18 are converted into their respective active forms to mediate further immunological responses. PYD: pyrin domain; LRR: leucine-rich repeats; CARD: caspase activation and recruitment domain; LTA: lipoteichoic acid.

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