Fig. 5: NLRP6 modulates cellular mechanisms to prevent carcinogenesis. | Mucosal Immunology

Fig. 5: NLRP6 modulates cellular mechanisms to prevent carcinogenesis.

From: The NLRP6 inflammasome in health and disease

Fig. 5

a, b NLRP6 deficiency increased the expression of genes involved in cell proliferation such as casein kinase ε (csnk1ε), ccl20, and SMARRC1 along with proto-oncogene Myc11 in the DSS-treated colon. c In a study using non-littermates control animals, NLRP6 prevented “dysbiosis”-induced IL-6 secretion, thereby preventing abnormal cell proliferation in the intestine. d, e NLRP6 augmented the expression of P14ARF, P21, and P53 and suppressed Mdm2 and cyclin D in gastric cancer cells to prevent tumor progression. Ccl20: CC-chemokine ligand 20; SMARRC1: a member of switch/sucrose nonfermentable chromatin remodeling complex; Ccl5: CC-chemokine ligand 5; Mdm2: murine double minute 2.

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