Fig. 6: Schematic model illustrating the molecular mechanism of claudin1 downregulation exacerbates mice asthma. | Mucosal Immunology

Fig. 6: Schematic model illustrating the molecular mechanism of claudin1 downregulation exacerbates mice asthma.

From: EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice

Fig. 6

Our working hypothesis was that claudin1 downregulation exacerbated HDM-triggered airway mucus secretionvia inducing the overexpression of MUC5AC. EGFR activation or transactivation in response to EGFR ligands (such as EGF or HBEGF) or IL-13 reduced expression of claudin1. Erlotinib, which inhibited EGFR signaling, reduced MUC5AC expression via restoring claudin1 expression.

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