Fig. 4: Type 1 IFN receptor (IFNAR) signalling on DCs is dispensable for the induction of antibody responses during Rotavirus infection. | Mucosal Immunology

Fig. 4: Type 1 IFN receptor (IFNAR) signalling on DCs is dispensable for the induction of antibody responses during Rotavirus infection.

From: αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Fig. 4

a XCR1-IFNARKO and b CD11c-IFNARKO mice were orally challenged with RV. The total number of total or RV-specific IgA+ B220+CD138− B cells (top; pre-gated on CD19+IgD−) and total or RV-specific IgA+ plasmablasts (bottom; B220−CD138+; pre-gated on CD19+IgD−) at 7 days post infection. Dots represent data from individual mice. Data were collected from a two and b four independent experiments with three mice per group. Two-way ANOVA was performed for statistical analysis with Tukey post hoc testing. *p < 0.05, **p < 0.01, ***p < 0.001. White symbols: HET; black symbols: KO; shaded bars: RV-infected.

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