Table 1 Lung histopathology analysis of Mtb-infected mice.

From: Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

  

Low dose

High dose

  

day 30

day 60

Moribund Gcnt1−/− (3)

day 27

 

Score

B6 (12)

Gcnt1−/− (13)

B6 (7)

Gcnt1−/− (6)

B6 (7)

Gcnt1−/− (10)

Perivascular lymphocytes

0

       
 

1

8.30

      
 

2

91.7

23.1

28.6

 

50.0

28.6

16.7

 

3

 

76.9

71.4

100

50.0

71.4

83.3

Peribronchiolar lymphocytes

0

       
 

1

44.4

55.6

57.1

33.3

 

14.3

 
 

2

55.6

33.3

42.9

50

50.0

42.9

66.7

 

3

 

11.1

 

16.7

50.0

42.9

33.3

Bronchiolar debris

0

70.0

66.7

42.9

50

 

14.3

 
 

1

30.0

22.2

57.1

33.3

 

57.1

10.0

 

2

 

11.1

 

16.7

66.7

14.3

20.0

 

3

    

33.3

14.3

70.0

Intra-alveolar necrotic debris

0

       
 

1

16.7

46.2

57.1

16.7

33.3

  
 

2

66.7

30.8

14.3

50

66.7

28.6

 
 

3

16.7

23.1

28.6

33.3

 

71.4

100

Necrosis

0

100

92.3

100

100

 

42.9

 
 

1

     

28.6

10.0

 

2

 

7.70

   

28.6

10.0

 

3

    

100

 

20.0

 

4

      

60.0

  1. Lung H&E sections of C57BL/6 (B6) or Gcnt1−/− infected animals were assessed and scored for the indicated histopathological features. Indicated is the % of animals with a certain score within the indicated experimental group. Indicated in brackets is the number of animals analysed per group.
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