Fig. 6: IL-33/ST2/IL-9/IL-9R signaling was involved in disruption of ocular surface epithelial barrier in allergic conjunctivitis. | Mucosal Immunology

Fig. 6: IL-33/ST2/IL-9/IL-9R signaling was involved in disruption of ocular surface epithelial barrier in allergic conjunctivitis.

From: IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation

Fig. 6

In ST2−/− mice, IL-9 (a), IL-9R (d), SPI 1, NFATc1, and NFATc2 (f) mRNA expression in the conjunctiva (Conj), cornea and/or CLN of EAC model was evaluated by RT-PCR. IL-9 protein expression in the conjunctiva (Conj) and CLN of EAC mice was detected by ELISA (b) and IF staining (c). IL-9R protein expression in the ocular surface (e) and PU.1, NFATc1 NFATc2 protein expression in CLN (g) were shown by IHC staining and IF staining respectively. Results shown are the mean ± SD (n = 5). Bar: 20 μm.

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